Principles of Bone and Joint Research by Peter Pietschmann

Author:Peter Pietschmann
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

7.6 Physiology of Fracture Healing

In the context of bone regeneration, the following principles are essential: Osteoconduction: It is passive process that involves adhesion and ingrowth of cells due to local material properties such as porosity and surface roughness.

Osteoinduction: It is an active process that involves recruitment and differentiation of cells. Growth factors which are able to induce ectopic bone formation, e.g., BMP-2, BMP-7, TGF-β1, IGF-1 (derived from bone), PDGF, EGF, VEGF, and TGF-β1 (from platelets).

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